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  • Features of 2C family substances: 2C-B, 2C-I

    Let's talk about psychedelics of 2C family, 2C-B and 2C-I.

    We do not promote psychoactive substance use, it is never completely safe. The safest choice is to never use drugs.

    2C (2C-x) is the general name for psychedelics of the phenethylamine family containing methoxy groups at the 2nd and 5th positions of the benzene ring. Most of the currently known 2C compounds were synthesized in the 1970s and 1980s by Dr. Alexander Shulgin, a well-known American biochemist and pharmacologist, author of many psychoactive substances. They are described in his cult book “PiHKAL” (“Phenethylamines I Have Known and Loved”).

    Term 2C was suggested by Dr. Shulgin. It’s an acronym for 2 carbon atoms between the benzene ring and the amino group.

    2C-substances have both hallucinatory and stimulating effects. By changing the chemical structure in one way or another, you can enhance certain effects. Structurally, 2C is similar to 3,4-methylenedioxy-N-methylamphetamine (MDMA, ecstasy).

    The 2C family includes a lot of substances. We will talk about two representatives, 2C-B and 2C-I.


    2C-B (4-Bromo-2,5-dimethoxyphenethylamine) is the first synthesized substance among the 2C family. Initially, the new drug was used in psychotherapeutic practice (in psychiatry). Subsequently, 2C-B was sold as an aphrodisiac under the trademark “Erox”.

    2C-B quickly gained popularity as a recreational drug. It is distributed in the form of a white crystalline powder that can be compressed into tablets or gelatin capsules. From the mid-1980s, 2C-B began to replace MDMA, as its effects were somewhat similar to those of ecstasy. The drug is characterized by increased empathy sensations at lower doses and pronounced visual effects and psychedelic experiences at higher doses.


    The spectrum of activity of 2C-B is very broad. The effects are described mainly as similar to those of LSD and MDMA. At the same time, the trip is different for different people, even if the dose, method of use and environment are the same.

    The main effects of 2C-B at common doses are the following:

    • pronounced hallucinogenic effects (the susceptibility of all senses increases);
    • strong changes in visual perception (even with eyes closed);
    • increased physical sensations (such effects can be perceived as unpleasant and scary);
    • sexual stimulation (works as an aphrodisiac);
    • empathogenic effects;
    • stimulating effect, psychological arousal (euphoria, anxiety, change in perception of time, confusion, insomnia, loss of appetite, anxiety, obsessive thoughts);
    • bouts of laughter;
    • increased attention to internal mental processes;

    With use of high doses the following effects are possible:

    • hallucinations with open eyes (multi-shaped distortions of space, red-green auras around objects);
    • impaired ability to communicate and focus adequately;
    • problems with coordination;
    • disorientation;
    • confusion, fear;
    • hypothermia, muscle spasms, shortness of breath, diarrhea;
    • headache;
    • at doses higher than 30-40 mg, panic attacks are possible;

    Short-term side effects:

    • severe burning of the nasal mucosa while sniffing;
    • accelerated pulse;
    • increase in blood pressure;
    • increase in body temperature;
    • reduction of hunger;
    • nausea;
    • sweating;
    • dizziness;
    • anxiety;
    • possible heart rhythm disorders;
    • unpleasant sensations in the gastrointestinal tract;
    • allergic reactions;
    • cough due to increased mucus secretion;
    • unwanted erection;
    • pupil dilation;
    • decreased visual acuity;

    Even after the main effects have subsided, light side effects may be felt for some time.


    2C-I (2,5-Dimethoxy-4-iodophenethylamine) is a psychedelic phenethylamine from 2C family, synthesized in 1976 by Shulgin. This compound is not used in medicine or industry, only for recreational purposes. It’s distributed in the form of white or light brown powder, may be crystalline, or compressed into a tablet.

    In terms of effects, 2C-I is similar to its analogue 2C-B, but is characterized by a longer activity. As an empathogen, it acts lighter than 2C-B, and may have a stimulating effect.


    2C-B and 2C-I are usually taken orally, but intranasal and inhalation use is also possible.

    WARNING! Such factors as individual perception, body weight, metabolism and psychological state are always important to consider when using psychoactive substances! Psychological state is especially important when using psychedelics. Start with a small dose, especially if you are an inexperienced user.

    • Light dose: 10-15 mg
    • Common dose: 15-25 mg
    • Strong dose: 25-45 mg

    When taken orally, the effects occur within a longer period, the first effects appear in 45-60 minutes after use, the plateau lasts 2-4 hours, the decline lasts 1-2 hours. The trip is quite long, up to 8 hours.

    When taken intranasally, the effects are felt almost immediately, in 1-10 minutes. The effects in this case are much stronger, but they last less. The plateau begins in 20-40 minutes and lasts 2-3 hours.

    The substance can be detected in the urine within 3 days after use.


    Mixing psychoactive substances is always more dangerous than using only one substance!

    You will find a calculator via this link where you can put in the names of substances and see the outcomes of combining them.

    2C-B, 2C-I + alcohol: Alcohol may increase the euphoric effects of 2C. At light doses, it weakens the psychedelic effects. In common and strong doses, alcohol leads to severe dehydration, nausea and physical exhaustion, as a result to a bad trip. Drinking large amounts of alcohol is not recommended, as it can easily lead to loss of consciousness and unpredictable behavior.

    2C-B, 2C-I + cannabis: Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics (synergy is unidirectional action of several substances, which leads to enhancement or change of effects, including undesirable effects). The combination significantly increases the sensitivity and cognitive effects of psychedelic drugs. It requires special attention, as it can significantly increase the likelihood of negative psychological reactions such as anxiety, confusion and psychosis.

    2C-B, 2C-I + benzodiazepines: Depending on the dosage, benzodiazepines can reduce the intensity of physical and visual effects. Memory problems may occur.

    2C-B, 2C-I + LSD, magic mushrooms: In combination with other psychedelics, physical, cognitive and visual effects may intensify and form strong synergies. The synergy between these substances is unpredictable, so the combination is not recommended. If you decide to take this combination, you should take much lower doses of both substances than you usually take separately.

    2C-B, 2C-I + ketamine, methoxetamine: In combination with dissociative substances, euphoria, dissociation and hallucinations may be greatly enhanced. This leads to greater confusion, delusions and psychosis.

    2C-B, 2C-I + amphetamines, cocaine: Stimulants increase anxiety and the risk of addiction (unpleasant thoughts). 2C substances also have a stimulating effect, so the combination of stimulating effects can cause unpleasant sensations.

    2C-B, 2C-I + MDMA: In combination with MDMA, physical and cognitive effects (euphoria, visual hallucinations) are greatly enhanced. The synergy between these substances is unpredictable, so much lower doses should be taken than when these substances are used separately. The combination may strengthen the neurotoxic effects of MDMA.


    1. Pay attention to the environment where you use psychedelics. It should be a pleasant place, and there should be people you know. Do not neglect the presence of the sitter, a person who will be with you during the trip. Do not use any psychoactive substances with strangers!

    2. Be careful with dosing, especially if you are a beginner. If you are taking 2С-B, 2C-I with another substance, take lower doses than when taking them separately.

    3. NEVER USE 2С-B, 2C-I WHILE DRIVING or in another situation requiring concentration and attention!

    4. Before experimenting with 2С, eat only light food and no later than 2 hours before taking the substance.

    5. After 2С experiments, you need a rest, so plan your trip when you don’t have important things to do the next day.

    6. People with unstable mental states and psychological problems should avoid using psychedelics.

    7. If you have the opportunity, check the substances before using it.


    1. As soon as unpleasant thoughts or fears begin to appear, try to block them immediately. Don’t panic. Calm down. Remember, it’s all just thoughts.

    2. Try to determine what you do not like right now, what causes unpleasant feelings. If possible, eliminate the stimulus.

    3. Try to do something that will deflect your attention. It’s better to do something than just watch a movie. However, watching a movie is also a good idea, if it is something positive, able to distract you from bad thoughts.

    4. If you have friends who understand the mechanism of psychedelic effects and know what a bad trip is, ask for help.

    5. Drink sweet tea (but not coffee) and eat sweets.

    6. If your friend has a bad trip, do not let him or her plunge into bad thoughts and fears. Talk to him or her, distract, stay with him or her, hold their hand.


    @OverdoseHelpBot is available on Telegram. There you can find information about what an overdose by various substances looks like and how to provide first aid to a person in such a situation.

    Symptoms of 2C-B and 2C-I intoxication, including acute, are psychostimulant and hallucinogenic.

    Symptoms of 2C overdose (one or more of the following):

    • unhealthy arousal;
    • sweating;
    • nausea, vomiting;
    • movement disorder, disorientation;
    • cramps, muscle tremors;
    • fast heartbeat;
    • muscle weakness;
    • intense hallucinations, mostly auditory, but visual, tactile and olfactory are also possible;
    • feeling out of control;
    • anxiety, fear, panic attacks;

    Don’t be afraid to call an ambulance – somebody’s life may depend on it. If, for some reason, you are very afraid to call an ambulance, call the parents or relatives of the overdosed person.

    You can call a free ambulance via the phone numbers 103 or 112.

    There is no criminal liability for calling an ambulance in case of an overdose. Contrary to popular belief, ambulance doctors are not required to report to the police about the cases of drug use. Police is called only if the ambulance crew has witnessed a criminal offense involving drug use.

    Before the ambulance arrives:

    • Do not leave the intoxicated person alone.
    • Provide fresh air access.
    • Try to divert the suffering person from anxious thoughts, talk about distracting topics.

    When the ambulance arrives, tell the doctors what the person consumed or could have consumed. This will help to more accurately provide special medical care.


    #2с #2cb #2ci

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